Journal: American Journal of Clinical Pathology
Article Title: Anal High-Grade Squamous Intraepithelial Lesions in Human Immunodeficiency Virus–Infected Men
doi: 10.1093/ajcp/aqw229
Figure Lengend Snippet: Examples of metaplastic and keratinized high-grade squamous intraepithelial lesion (HSIL) cells in cytology samples. A, Metaplastic-type HSIL cells (arrow) are small cells with scant basophilic cytoplasm, hyperchromatic nuclei, and high nuclear-to-cytoplasmic ratio. B, A case displaying both types of HSIL cells: metaplastic (arrow) next to a keratinizied HSIL cell (arrowhead). C, Keratinized HSIL cell (arrow) displays similar high-grade nuclear features but with scant orangeophilic cytoplasm, consistent with keratinization. D, A cluster of keratinized HSIL cells with dense orangeophilic cytoplasm (arrow), including one dyskeratotic cell (arrowhead). (ThinPrep, Papanicolaou stain, x400)
Article Snippet: The cells were preserved in liquid-based cytology medium for ThinPrep (Cytyc, Boxborough, MA) and stained with the Papanicolaou stain.
Techniques: Papanicolaou Stain